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![]() It was reported that Helix aspersa maxima snail mucus shows antitumor activity against human melanoma cells 12 and Cornu aspersum snail lyophilisate significantly reduces the survival rate of Caco-2 colon cancer cells 20. Numerous scientific reports indicate the cytotoxic properties of snail mucus in relation to various cell lines, including cancerous 11, 12, 13, 14, 15, 16, 17, 18, 19. One of the current trends in world science is the search for biologically active substances derived from living organisms and their use in biotechnological processes in the pharmaceutical, cosmetic, food and other industries. This generates the need to search for new biologically active compounds with anti-tumor potential against this type of cancer. Based on the available data, there is currently no specific drug approved for the treatment of superficial malignant melanoma. Imiquimod is the only topical use drug approved by the Food and Drug Administration (FDA), although its main applications are treatment of keratinization lesions, basal cell carcinoma, genital and anal warts. Currently, a cream containing imiquimod is used to treat stage 0 melanoma (melanoma limited to the epidermis) 8, 9, 10. Therefore, it is extremely important to implement rapid diagnosis and treatment in the early stages of melanoma, when the chances of cure are as high as 80% 3. The rate of metastasis, its location and number of metastases significantly affects the survival of patients, which is why it is so important to find a way to slow this process 6, 7. Melanoma spreads quickly to various distant organs, which makes treatment difficult or impossible. Skin melanoma is a cancer with a rapid development rate and high drug resistance 3, 4, 5. ![]() However, the most dangerous skin cancer is malignant melanoma, which causes 1.5–2% of all malignant neoplasms, and its primary location is skin in 95% of cases 1, 3, 4. The most common non-melanoma skin cancer (NMSC) are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), which represent 95% of all skin cancers and up to 35% of primary human malignant neoplasms 1, 2, 3. These factors can cause pathophysiological and morphological changes or mutagenesis of the genetic material, often leading to carcinogenesis. Human skin, as an organ most exposed to contact with the external environment, is subjected to various damaging factors. The impact of the mucus on human keratinocytes CCD 1106 KERTr and malignant melanoma cells A-375 was examined using MTT assay and SRB assay, which allowed us to determine the cell metabolic activity and cell number after treating them with slug mucus isolated from Limax maximus and Arion rufus decreased human keratinocytes and melanoma cells metabolic activity as well as manifested properties of reducing the number of cells in both tested cell lines, and therefore can be a source of biologically active substances with anticancer potential. Tested mucus were isolated using the new self-developed method which is safe for the environment and the animal donors. ![]() Therefore, the aim of the study was to assess the properties of biologically active compounds in sterile mucus isolated from slugs Limax maximus and Arion rufus. Malignant melanoma originates from melanocytes, develops very quickly and is associated with poor prognosis. Molluscs are one of the sources of biologically active substances, which are now intensively studied, especially for their anti-cancer properties.
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